https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 The role of truncated p53 isoforms in the DNA damage response https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53018 Wed 28 Feb 2024 16:09:22 AEDT ]]> Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49890 Wed 14 Jun 2023 17:16:17 AEST ]]> Regulation of apoptosis induced by targeting the RAF/MEK/ERK pathway in human melanoma https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15254 Wed 11 Apr 2018 16:23:04 AEST ]]> OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14361 Wed 11 Apr 2018 13:27:51 AEST ]]> The role of altered nucleotide excision repair and UVB-induced DNA damage in melanomagenesis https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12520 Wed 11 Apr 2018 12:41:53 AEST ]]> RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:28314 Wed 11 Apr 2018 12:40:55 AEST ]]> Inhibition of clathrin by pitstop 2 activates the spindle assembly checkpoint and induces cell death in dividing HeLa cancer cells https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:20085 Wed 11 Apr 2018 12:17:41 AEST ]]> Plasma surface functionalization: A comprehensive review of advances in the quest for bioinstructive materials and interfaces https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51296 Wed 07 Feb 2024 14:35:52 AEDT ]]> Neuronal Cell Death https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47641 Tue 24 Jan 2023 14:38:00 AEDT ]]> RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50999 Tue 15 Aug 2023 11:52:40 AEST ]]> A general model for cell death and biomarker release from injured tissues https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42585 Thu 25 Aug 2022 15:17:17 AEST ]]> The implication of autophagy in cell fate of human bone marrow-derived mesenchymal stem cells exposed to titanium dioxide nanoparticles https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37991 Thu 22 Jul 2021 16:00:46 AEST ]]> The double life of RIPK1 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50344 Thu 20 Jul 2023 14:26:55 AEST ]]> Sunlight and vitamin D affect DNA damage, cell division and cell death in human lymphocytes: a cross-sectional study in South Australia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21575 Sat 24 Mar 2018 08:00:42 AEDT ]]> Phagoptosis: cell death by phagocytosis: plays central roles in physiology, host defense and pathology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:26189 Sat 24 Mar 2018 07:24:10 AEDT ]]> Differential cell death decisions in the testis: evidence for an exclusive window of ferroptosis in round spermatids https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36974 Fri 24 Jul 2020 14:55:41 AEST ]]> A novel naphthalimide that selectively targets breast cancer via the arylhydrocarbon receptor pathway https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:38322 50 value of 100 nM is greater than 500-fold more sensitive to NAP-6 compared with other tumour derived cell models. Within 1 h exposure of these cells to NAP-6, CYP1A1 expression increases 25-fold, rising to 250-fold by 24 h. A smaller concurrent increase in CYP1A2 and CYP1B1 is also observed. Within 24 h these cells present with DNA damage as evident by enhanced H2AXγ expression, cell cycle checkpoint activation via increased CHK2 expression, S-phase cell cycle arrest and cell death. Specific small molecule inhibitors of the AHR and CYP1 family ameliorate these events. A positive luciferase reporter assay for NAP-6 induced XRE binding further confirms the role of the AHR in this phenomenon. Non-sensitive cell lines fail to show these biological effects. For the first time we identify 2-(2-aminophenyl)-1H-benzo[de]isoquinoline-1,3(2H)-dione as a new AHR ligand that selectively targets breast cancer.]]> Fri 03 Sep 2021 14:57:31 AEST ]]>